Neuromodulation of Epilepsy Network
نویسندگان
چکیده
منابع مشابه
Neuromodulation in Epilepsy and in Chronic Pain
Because the probability of resistant patients to achieve complete remission with new antiepileptic drugs appears to be less than 10%, surgical interventions remain the main option to treat patients with intractable epilepsy. However, results do not remain successful enough, since only 29–65% of the patients were free of seizures after temporal lobe and/or localized neocortical resections. Inten...
متن کاملAstroglial Networks and Implications for Therapeutic Neuromodulation of Epilepsy
Epilepsy is a common chronic neurologic disorder affecting approximately 1% of the world population. More than one-third of all epilepsy patients have incompletely controlled seizures or debilitating medication side effects in spite of optimal medical management. Medically refractory epilepsy is associated with excess injury and mortality, psychosocial dysfunction, and significant cognitive imp...
متن کاملRole of The Purinergic Neuromodulation System in Epilepsy
Adenosine has long been considered an endogenous anti-epileptic compound. This concept was based on the widespread distribution of adenosine A1 receptors (A1R), which are mostly located in excitatory synapses; here, A1R inhibit glutamate release, decrease glutamatergic responsiveness and hyperpolarise neurons. However, the combined observation that synaptic A1R undergo desensitisation in chroni...
متن کاملStimulation and Neuromodulation in the Treatment of Epilepsy
Invasive brain stimulation technologies are allowing the improvement of multiple neurological diseases that were non-manageable in the past. Nowadays, this technology is widely used for movement disorders and is undergoing multiple clinical and basic science research for development of new applications. Epilepsy is one of the conditions that can benefit from these emerging technologies. The obj...
متن کاملCellular, synaptic and network effects of neuromodulation
All network dynamics emerge from the complex interaction between the intrinsic membrane properties of network neurons and their synaptic connections. Nervous systems contain numerous amines and neuropeptides that function to both modulate the strength of synaptic connections and the intrinsic properties of network neurons. Consequently network dynamics can be tuned and configured in different w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Human Neuroscience
سال: 2016
ISSN: 1662-5161
DOI: 10.3389/conf.fnhum.2016.220.00117